Isak, who has been the subject of interest from Liverpool, has missed the Magpies’ pre-season tour of Asia amid speculation over his future.
Newcastle are now returning home after their trip concluded with a 1-1 draw against Tottenham in Seoul on Sunday and Howe hopes the Sweden international will report back as normal.
Howe told The Chronicle after the game: “Of course I’d like him to but whether or not he will, I don’t know at this moment in time.
“Other people have been dealing with that situation back at home.”
Sweden international Isak did not travel with the squad due to a thigh injury but the player reportedly wants to explore the possibility of a move.
Newcastle rejected an offer of £110million from Liverpool for the 25-year-old, who has three years remaining on his contract and is valued by the club at £150million.
Isak has trained with former club Real Sociedad while Newcastle have been away but is now thought to be returning to the UK.
Newcastle, meanwhile, are understood to have had a bid worth up to £69.7million for RB Leipzig forward Benjamin Sesko rejected by the German club.
Slovenia international Sesko has also been linked with Manchester United.
